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Betaine (Trimethylglycine)

Introduction to Betaine (Trimethylglycine)

Betaine (trimethylglycine) functions very closely with choline, folic acid, vitamin B12, and a form of the amino acid methionine known as S-adenosylmethionine (SAMe). All of these compounds function as “methyl donors.” They carry and donate methyl molecules to facilitate necessary chemical processes. The donation of methyl groups by betaine is very important to proper liver function, cellular replication, and detoxification reactions. Betaine also plays a role in the manufacture of carnitine and serves to protect the kidneys from damage. Betaine is closely related to choline. The difference is that choline (tetramethylglycine) has four methyl groups attached to it. When choline donates one of these groups to another molecule, it becomes betaine (trimethylglycine). If betaine donates one of its methyl groups, then it becomes dimethylglycine.

Sources of Betaine (Trimethylglycine)

Dietary sources of betaine include fish, beets, and legumes. Betaine is most widely available as betaine hydrochloride (betaine-HCl), but that form is used primarily as a source of hydrochloric acid for people with hypochlorhydria (low stomach acid). The forms used specifically to provide betaine are betaine citrate and betaine aspartate. These forms have also been used to improve liver function.

Known Side Effect of Using Betaine (Trimethylglycine)

No side effects with betaine at recommended levels have been noted. At the time of writing, there were no well-known drug interactions with betaine.

Supportive Formulas

Many years have been spent creating the Phytobiophysics formulas that are made from carefully researched combinations of essences from many flowers and plants. We believe that essences enable the body to heal by dealing with the underlying causal emotional trauma so encouraging the body’s own healing process.


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