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"Every patient teaches you something new and important."

Diana Mossop

Gastric Cancer

Information Regarding Gastric Cancer

Gastric cancer is a disease in which malignant cancer cells form in the lining of the stomach.

The stomach is a J-shaped organ in the upper abdomen. It is part of the digestive system, which processes nutrients vitamins, minerals, carbohydrates, fats, proteins, and water in foods that are eaten and helps pass waste material out of the body. Food moves from the throat to the stomach through a hollow, muscular tube called the esophagus. After leaving the stomach, partly-digested food passes into the small intestine and then into the large intestine the colon.

The wall of the stomach is made up of 3 layers of tissue:

  • the mucosal innermost layer,
  • the muscularis middle layer,
  • and the serosal outermost layer.

Gastric cancer begins in the cells lining the mucosal layer and spreads through the outer layers as it grows.Stromal tumors of the stomach begin in supporting connective tissue and are treated differently from gastric cancer. Age, diet, and stomach disease can affect the risk of developing gastric cancer.

Risk factors include the following:
  • Helicobacter pylori infection of the stomach.
  • Chronic gastritis inflammation of the stomach.
  • Older age.
  • Being male.
  • A diet high in salted, smoked, or poorly preserved foods and low in fruits and vegetables.
  • Pernicious anemia.
  • Smoking cigarettes.
  • Intestinal metaplasia.
  • Familial adenomatous polyposis FAP or gastric polyps.
  • A mother, father, sister, or brother who has had stomach cancer.

Possible signs of gastric cancer include indigestion and stomach discomfort or pain. These and other symptoms may be caused by gastric cancer or by other conditions.In the early stages of gastric cancer, the following symptoms may occur:
  • Indigestion and stomach discomfort.
  • A bloated feeling after eating.
  • Mild nausea.
  • Loss of appetite.
  • Heartburn.

In more advanced stages of gastric cancer, the following symptoms may occur:
  • Blood in the stool.
  • Vomiting.
  • Weight loss unexplained.
  • Stomach pain.
  • Jaundice yellowing of eyes and skin.
  • Ascites build-up of fluid in the abdomen.
  • Difficulty swallowing.

A doctor should be consulted if any of these problems occur.

Tests that examine the stomach and esophagus are used to detect find and diagnose gastric cancer.The following tests and procedures may be used:
  • Physical exam and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patients health habits and past illnesses and treatments will also be taken.
  • Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual higher or lower than normal amount of a substance can be a sign of disease in the organ or tissue that produces it.
  • Complete blood count: A procedure in which a sample of blood is drawn and checked for the following:The number of red blood cells, white blood cells, and platelets. The amount of hemoglobin the protein that carries oxygen in the red blood cells. The portion of the sample made up of red blood cells.
  • Upper endoscopy: A procedure to look inside the esophagus, stomach, and duodenum first part of the small intestine to check for abnormal areas. An endoscope a thin, lighted tube is passed through the mouth and down the throat into the esophagus.
  • Fecal occult blood test: A test to check stool solid waste for blood that can only be seen with a microscope. Small samples of stool are placed on special cards and returned to the doctor or laboratory for testing.
  • Barium swallow: A series of x-rays of the esophagus and stomach. The patient drinks a liquid that contains barium a silver-white metallic compound. The liquid coats the esophagus and stomach and x-rays are taken. This procedure is also called an upper GI series.
  • Biopsy: The removal of cells or tissues so they can be viewed under a microscope to check for signs of cancer. A biopsy of the stomach is usually done during the endoscopy.
  • CT scan CAT scan: A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.

Certain factors affect prognosis chance of recovery and treatment options. The prognosis chance of recovery and treatment options depend on the following:
  • The stage and extent of the cancer whether it is in the stomach only or has spread to lymph nodes or other places in the body.
  • The patients general health.
  • When gastric cancer is found very early, there is a better chance of recovery.
  • Gastric cancer is often in an advanced stage when it is diagnosed.

At later stages, gastric cancer can be treated but rarely can be cured. Taking part in one of the clinical trials being done to improve treatment should be considered.

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