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Diana Mossop

17-beta-hydroxysteroid dehydrogenase deficiency

Definition

The hormones estrogen and androgen play critical roles in the development of sexual organs. 17b-hydroxysteroid dehydrogenase isozyme (17�-HSD) acts as a catalyst between the biologically inactive and active types of hormones. Any deviation from this normal process results into various abnormal conditions.

Prevalence

It is estimated in the Netherlands that 1 case in every 147,000 births show symptoms of 17b-hydroxysteroid dehydrogenase deficiency which makes this deficiency very rare.

Role

Steroid hormones have biological activities that are being regulated by some body enzymes. They are often regulated at the pre-receptor phase by such enzymes as 17 beta-hydroxysteroid dehydrogenases. These enzymes do not only regulate steroid concentrations but also bile and fatty acids in the body. The 17 beta-hydroxysteroid dehydrogenase enzyme is prevalent in all life forms (whether they are invertebrates, vertebrates or microorganisms). Malfunctions occur when this enzyme becomes deficient or imbalance in any way.

Recorded Mutations

The recorded mutations of this syndrome are now up to 16 in number. The numbers are subdivided into 12 mutations that are missense, 3 mutations on splice junction, and a single tiny deletion which becomes an untimely stop codon.

Hormonal Conditions with the Deficiency

Studies have been done to prove that pseudohermaphroditism is a result of the deficiency. It has been observed that subjects develop symptoms at puberty (either virilization or gynaecomastia). It also showed that the level of plasma androstenedione was about 4-5 times more than the normal level. The level of plasma testosterone, however, was very low when compared to the normal level.

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Traditional Chinese Medicine refers to a broad range of medicine practices sharing common theoretical concepts which have been developed in China and are based on a tradition of more than 2,000 years.