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Diana Mossop

Muckle-wells syndrome

Definition

First described in 1962 by Thomas James Muckle and Michael Vernon Wells, Muckle-Wells syndrome is also known as Urticaria-deafness-amyloidosis (UDA). It is a rare autosomal disease, which causes sensorineural deafness, recurrent hives, and can lead to amyloidosis. MWS happens when a mutation in the CIAS1 gene leads to increased activity of the cryopyrin protein. The disorder is closely related to two other syndromes, familial cold urticaria and neonatal onset multisystem inflammatory disease.

Diagnosis

Diagnostic criteria are purely clinical but genetic diagnosis is considered currently feasible. There are only moderate non-specific signs of inflammation during the course of inflammatory attacks associated to the disorder. Biochemical analyses may be useful to exclude certain diseases that can be considered as a function of the clinical signs present.

Symptoms and Signs

The common symptom for MWS is inflammation all over the body, which includes, fever, arthritis, and malaise. The chronic inflammation associated with MWS can lead to deafness. Prolonged inflammation can also lead to deposition of proteins in the kidney, a condition known as amyloidosis.

Causes

The disease is caused by a defect in the CIAS1 gene, which creates the protein cryopyrin.

Testimonials

We have a growing number of testimonials from patients who want to spread the word about Phytobiophysics.

Triathlon Champion after serious Sports Injury I first came to see Diana Mossop in 1998 as I had recurring chest infections which were preventing me from doing my hobby, training and racing in the sport of triathlon###;### ‘Ev…

When I visited you a month ago I was suffering from serious Oedema, my ankles were very swollen – I take Lisinopril for my heart and my doctor prescribed water tablets. Unfortunately they made me feel so ill I did not wont to t…

Some 16 months ago following a long period of ill health and frequent visits to doctors, In desperation I visited Diana. I was at the time suffering from a progressively debilitating shoulder pain and a re-occurrence of chroni…

I feel awful that it has taken so long to do but I really wanted to let you know how much I appreciate all your help with my daughter, J???. Right from when she was a baby she had never slept well and she grew into a lively chi…

My illness came 3 years ago as quite a shock it all happened so quickly. Happily married loving working as a Reflexologist -when more or less overnight my whole world changed. I had these terrible pains and fatigue which left me f…

As you are aware, my son, who is six years old, was a perfectly normal baby, until he had his MMR vaccine. After this, he was slightly unwell, I then noticed almost immediately that he had no eye contact with me or anyone else, an…

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Diana Mossop was commissioned as an Officer in the WRAC in 1966 and served mostly in the Far East where by the age of just 24 she was promoted to Captain and was appointed as Commanding Officer of the WRAC in Hong Kong.