"A really good practitioner never stops learning and is never qualified as there is always something more to learn."

Diana Mossop

Muckle-wells syndrome

Definition

First described in 1962 by Thomas James Muckle and Michael Vernon Wells, Muckle-Wells syndrome is also known as Urticaria-deafness-amyloidosis (UDA). It is a rare autosomal disease, which causes sensorineural deafness, recurrent hives, and can lead to amyloidosis. MWS happens when a mutation in the CIAS1 gene leads to increased activity of the cryopyrin protein. The disorder is closely related to two other syndromes, familial cold urticaria and neonatal onset multisystem inflammatory disease.

Diagnosis

Diagnostic criteria are purely clinical but genetic diagnosis is considered currently feasible. There are only moderate non-specific signs of inflammation during the course of inflammatory attacks associated to the disorder. Biochemical analyses may be useful to exclude certain diseases that can be considered as a function of the clinical signs present.

Symptoms and Signs

The common symptom for MWS is inflammation all over the body, which includes, fever, arthritis, and malaise. The chronic inflammation associated with MWS can lead to deafness. Prolonged inflammation can also lead to deposition of proteins in the kidney, a condition known as amyloidosis.

Causes

The disease is caused by a defect in the CIAS1 gene, which creates the protein cryopyrin.

Testimonials

We have a growing number of testimonials from patients who want to spread the word about Phytobiophysics.

I am writing to thank you for your treatment of me and my family. I first came to you in early March this year, when I had been recently diagnosed as a Diabetic. I was shocked and upset about this diagnosis, fearful of the futu…

Having suffered from skin problems all my life, and having a doctor in the family, I am well placed to comment on the short-comings of traditional medicine in treating conditions like mine. After years of dragging vainly betwee…

Client of Gabriella Divine. Irene Feb to July 2012 I am a Swedish woman, born 1956. I would like to share my story with you, a story about a healing journey inside out and outside in. Which too include Phytobiophysics formula…

Many thanks for the remedies you sent, at present still in the trial period, my son is on the Dr’s tablets as well still having a wet night here there. Myself better but slight metal taste now and then in my mouth, but I am sure t…

I went to see my GP in February 1998 after experiencing pins and needles in my left arm and fingers. At first I thought it may have been just a trapped nerve but after it continued for a week and I began to feel worse in myself no…

I feel awful that it has taken so long to do but I really wanted to let you know how much I appreciate all your help with my daughter, J???. Right from when she was a baby she had never slept well and she grew into a lively chi…

blog comments powered by Disqus
The Institute of Phytobiophysics offers comprehensive formal Post graduate training to Practitioners of all medical modalities and was accredited by the Guild of Professional Practitioners in 1997.