"Good health is your most precious asset."
First described in 1962 by Thomas James Muckle and Michael Vernon Wells, Muckle-Wells syndrome is also known as Urticaria-deafness-amyloidosis (UDA). It is a rare autosomal disease, which causes sensorineural deafness, recurrent hives, and can lead to amyloidosis. MWS happens when a mutation in the CIAS1 gene leads to increased activity of the cryopyrin protein. The disorder is closely related to two other syndromes, familial cold urticaria and neonatal onset multisystem inflammatory disease.
Diagnostic criteria are purely clinical but genetic diagnosis is considered currently feasible. There are only moderate non-specific signs of inflammation during the course of inflammatory attacks associated to the disorder. Biochemical analyses may be useful to exclude certain diseases that can be considered as a function of the clinical signs present.
The common symptom for MWS is inflammation all over the body, which includes, fever, arthritis, and malaise. The chronic inflammation associated with MWS can lead to deafness. Prolonged inflammation can also lead to deposition of proteins in the kidney, a condition known as amyloidosis.
The disease is caused by a defect in the CIAS1 gene, which creates the protein cryopyrin.
Patient UK information on Muckle-wells syndrome.
We have a growing number of testimonials from patients who want to spread the word about Phytobiophysics.
I want to thank you most sincerely for looking after me and getting me though six months of chemotherapy.
I know that the flower formulas have been a big help me.
Keeping me so well though it all. I am feeling…
Many thanks for the remedies you sent, at present still in the trial period, my son is on the Dr’s tablets as well still having a wet night here there. Myself better but slight metal taste now and then in my mouth, but I am sure t…
We have recently returned from annual leave and T???'s face looks so much thinner. A friend that has not seen her for a fortnight remarked on what a large change she has seen in her. She said that she thought she used to look like…
I first visited Diana in 1990 having being told by my Doctor that there was nothing else than could do to help me get rid of the Glandular Fever I had been suffering with for several years. It is a very debilitating illness so I w…
I would like to thank you for all the help that you have given me over the last 18 months. Although I was aware of how much you have helped other members of my family for various ailments, I confess that I remained sceptical — to …
Daniel was a normal lively 1 year old, very healthy and rarely ill. He was due to have his MMR vaccination with a flu [Swine flu] vaccination to follow 10 days later.
I was concerned that it was too much for …
Phytobiophysics® Formulas are a food supplement and do not claim to diagnose, treat or cure medical conditions.
The information provided on this website is the personal opinion of Diana Mossop and/or Anthony Mossop unless otherwise stated.
All data and information provided on this site is for informational purposes only. DianaMossop.com makes no representations as to accuracy, completeness, currentness, suitability, or validity of any information on this site and will not be liable for any errors, omissions, or delays in this information or any losses, injuries, or damages arising from its display or use. All information is provided on an as-is basis.