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Anthony Mossop

Krause-Kivlin syndrome

Definition

Krause-van Schooneveld-Kivlin syndrome (also known as Peters-plus sundrome) is a hereditary syndrome that primarily affects the eyes, growth and development of the individual. It is also called Krause-Kivlin syndrome or Peters-plus syndrome.

Diagnosis

MRI of the brain and spinal cord; echocardiogram; and ocular ultrasonogram may be performed based on the clinical findings from the physical examination.

Symptoms and Signs

Symptoms of Krause-Kivlin syndrome include: mental retardation; growth deficiency; low birth weight; round face; primonent forehead; widely-spaced eyes; long philtrum; cupid-bow shape of upper lip; thin vermilion border; small and malformed ears; small lower jaw; broad neck; preauricular pits; Peters anomaly; anterior eye chamber cleavage disorder; nystagmus; glaucoma; central cornea leukoma; central defect of Descemet's membrane; shallow anterior chamber; short limbs; decreased range of elbow motion; broad and short hands; broad and short feet; fifth finger clinodactyly; cardiac defects; atrial septal defects; ventricular septal defects; pulmonary stenosis; hydronephrosis; duplication of kidneys; undescended testes; infant feeding problems; delayed developmental milestones; and impaired vision.

Causes

The cause of Peters anomaly is not known; it may be the result of genetic factors, environmental factors, or both. The critical event must arise in the first trimester of pregnancy during the formation of the anterior chamber.

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Diana Mossop was commissioned as an Officer in the WRAC in 1966 and served mostly in the Far East where by the age of just 24 she was promoted to Captain and was appointed as Commanding Officer of the WRAC in Hong Kong.