DNNMasters SEO URL Provider is running in evaluation mode. Please purchase license on www.dnnmasters.com


"My Mission is to bring affordable, ethical and effective healthcare, using the natural healing power of plants, to the children of the world, not just my children but all children, in my life time."

Diana Mossop

11 beta hydroxysteroid dehydrogenase type 2 deficiency


11Beta-hydroxysteroid dehydrogenase type 2 deficiency also known as (11beta-HSD2) is one of the most common causes of retention of sodium and serious cases of hypertension. This happens when glucocorticoids are admitted to the mineralocorticosteroid receptors which are non-selective.

Manifestations of the Disease

In 1974, the first case of hypertension due to 11 beta-hydroxysteroid dehydrogenase type 2 deficiency was first reported by Werder and some of his colleagues. The type of hypertension that was then observed was characterized as juvenile, had low-aldosterone and low-renin. Aside from hypertension, other symptoms include hypokalemia; polyuria; very low, abnormal birth weight; some cases of still birth; polydipsia; nephrocalcinosis; renal disease; and hypoaldosteronemia. Hypertension caused by the deficiency of 11 beta-hydroxysteroid dehydrogenase type 2 enzyme could range from the grave disease is often diagnosed among children to the milder case usually diagnosed among adults (this comprises about 20-30% of reported cases). Over the years, there have been cases of hypertension which have been reported to have affected renal transport of sodium. These cases are known as monogenic hypertension cases. Although hypertension is commonly associated with the deficiency of this enzyme, the fact that it really causes this illness has yet to be established. There are evidences here and there that point to the deficiency as a reason for hypertension but none have been recognized as scientific fact.


It has been observed that among African-Americans, the leading cause of end-phase renal disease is hypertension with low-renin (a type of hypertension that is salt-dependent). It is believed that the deficiency is highly prevalent among the black population.


It is also important to comprehend the role of the 11 beta-hydroxysteroid dehydrogenase type 2 when it comes to regulating a person's blood pressure. This will be an aid in understanding what would happen when there is a deficiency of this enzyme. This enzyme actually inactivates 11-hydroxy steroids found in the kidneys. This action helps in protecting the mineralocorticoid receptor (which is a non-selective receptor) from being occupied by the glucocorticoids. This gene can be found in human thyroid, pancreas and placenta. Gene mutations could result into the hypertensive syndrome known as AME or apparent mineralocorticoid excess. When this type of hypertension occurs, the results are usually renal retention of sodium, hypertension that is salt-dependent and also hypokalemia.


We have a growing number of testimonials from patients who want to spread the word about Phytobiophysics.

I would like to thank you for all the help that you have given me over the last 18 months. Although I was aware of how much you have helped other members of my family for various ailments, I confess that I remained sceptical — to …

How we can ever thank you for all the help you have given us in “finders” our “lost” little boy today 3½ . Through your flower formulas he has improved so much that people now think we are wrong when we say that he is Autistic. He…

I went to see my GP in February 1998 after experiencing pins and needles in my left arm and fingers. At first I thought it may have been just a trapped nerve but after it continued for a week and I began to feel worse in myself no…

Dearest Diana - thought I'd write you a letter, To just let you know that I'm feeling much better, I came to your clinic in a state of despair, And left feeling " New ", like a breath of fresh air. I’d tried all the doctors, di…

Hopefully you would have received our wonderful news from your assistant, I'm pregnant! You may recall that we came to see you firstly in Jersey in September last year and then in London in February in the hope you could help u…

Dear Diana I want to thank you most sincerely for looking after me and getting me though six months of chemotherapy. I know that the flower formulas have been a big help me. Keeping me so well though it all. I am feeling…

blog comments powered by Disqus
Phytobiophysics is being used by practitioners in many countries in the world stretching from Vancouver in the West to Maylasia and Hong Kong in The East